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ORIGINAL ARTICLE
Year : 2021  |  Volume : 18  |  Issue : 1  |  Page : 94

Drug release kinetics and biological properties of a novel local drug carrier system


1 Department of Dental Biomaterials, School of Dentistry; Research Center for Science and Technology in Medicine, Tehran University of Medical Sciences, Tehran, Iran
2 Department of Restorative Dentistry, Dental Sciences Research Center, School of Dentistry, Guilan University of Medical Sciences, Rasht, Iran
3 Department of Resin and Additives, Institute for Color Science and Technology, Tehran, Iran

Correspondence Address:
Dr. Mehrsima Ghavami-Lahiji
Department of Restorative Dentistry, School of Dentistry, Guilan University of Medical Sciences, Gums Academic Complex, Fuman-Saravan Road, Rasht
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1735-3327.330875

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Background: The purpose of this in vitro study was to investigate drug release kinetics and cytotoxicity of a novel drug delivery system for treatment of periodontitis. Materials and Methods: This in vitro study addresses the fabrication of a polycaprolactone/alginic acid-based polymeric film loaded with metronidazole, as a basic drug in the treatment of periodontal diseases. Films were prepared by solvent casting technique. Four formulations with different percentages of drug by weight (3%, 5%, 9%, and 13%) were prepared. Drug release kinetics were investigated using ultraviolet–visible spectroscopy during (one week). Data were analyzed using repeated measures ANOVA. Cytotoxicity of drug-loaded system extracts was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay using L929 cells after 24-h incubation. The results were evaluated according to ISO standard 10993-5 and assessed using ANOVA and Tukey's tests at a significance level of P < 0.05. Results: All polymeric films showed a burst drug release followed by a gradual release. Drug release data were fitted well with the first-order kinetic model in all drug-containing formulations indicating that drug release is a fraction of remaining drug in the matrix. Drug release is mainly driven by diffusion of medium into the composite matrix. 3%wt metronidazole-containing formulation exhibited the best MTT result. Conclusion: The findings of this study supported the synthesis of drug-loaded periodontal films with 3% metronidazole due to better biological properties along with the ability of acceptable drug release to eradicate anaerobic periodontal bacteria.


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