Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
  • Users Online: 2374
  • Home
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 2022  |  Volume : 19  |  Issue : 1  |  Page : 58

Evaluation of Epstein–Barr virus expression in oral squamous cell carcinomas


1 Dental Materials Research Center, Department of Oral and Maxillofacial Pathology, Dental School. Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Oral and Maxillofacial Pathology, Dental Research Center, Dental School, Isfahan University of Medical Science, Isfahan, Iran
3 Department of Oral and Maxillofacial Pathology, Dental Students' Research Committee, Dental School, Isfahan University of Medical Sciences, Isfahan, Iran

Correspondence Address:
Dr. Laleh Maleki
Dental Research Center, Dental School, Isfahan University of Medical Science, Isfahan
Iran
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1735-3327.351347

Rights and Permissions

Background: Oral squamous cell carcinoma (OSCC) is one of the most common cancers. Epstein–Barr virus (EBV) has been related to throat-esophageal and gastric cancers. The aim of this study was to evaluate the prevalence of EBV in OSCC. Materials and Methods: This descriptive-analytical cross-sectional study was performed on 48 samples recorded in the archives of the Oral Pathology Department of Isfahan Dental School with definitive diagnosis of OSCCs prepared by excisional biopsy. Samples were selected in different age groups, locations, and genders. The grade of the tumor malignancy was determined based on Annreroth's classification. The EBV expression was determined by immunohistochemical (IHC) staining. The data were entered into SPSS software and statistically analyzed by t-test, Chi-square, and Fisher's exact test. Significance level was considered P < 0.05. Results: IHC staining for EBV was positive in 25 samples (52%). There was no significant relationship between EBV expression and mean age, gender, clinical feature, and grade of tumor differentiation (P > 0.05). A significant difference was observed between the EBV expression and location (P = 0.035). Furthermore, a significant difference was observed between the grade of tumor and staining intensity distribution index of EBV (P = 0.005). Conclusion: EBV expression was observed in most of the OSCCs, especially in poorly differentiated tumors. The pathogenesis of OSCCs may be related with EBV. OSCCs in buccal mucosa and floor of the mouth have more frequently of EBV expression. Future studies on the mechanisms of EBV and their role in OSCC are required with larger sample sizes.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1720    
    Printed56    
    Emailed0    
    PDF Downloaded249    
    Comments [Add]    

Recommend this journal