Effect of nystatin and licorice on yeasts isolated from the oral lesions of patients with cancer under chemotherapy (in vitro study)
Faezeh Khozeimeh1, Parvin Dehghan2, Negin Yaghoobi3, Mehrnoush Maheronnaghsh4, Mona Bazazzadeh5, Seyedeh Negin Noorbakhsh2
1 Dental Research Center, Department of Oral Medicine, Dental Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Tehran, Iran
3 Department of Prosthodontics, Dental Research Center, Dentistry Research Institute, Tehran University of Medical Science, Tehran, Iran
4 Department of Mycology and Parasitology, School of Medicine, Isfahan University of Medical Sciences, Tehran, Iran
5 Department of Advanced Education in General Dentistry, Columbia University College of Dental Medicine, New York, USA
Dr. Negin Yaghoobi
Department of Prosthodontics, School of Dentistry, Tehran University of Medical Sciences, North Kargar Ave, Tehran
Source of Support: None, Conflict of Interest: None
Background: Oral candidiasis is one of the most common manifestations of patients with cancer under chemotherapy. Due to many side effects of chemical antifungal products and various advantages of herbal extracts like licorice, this study was performed to compare the antifungal effects of nystatin and licorice on yeasts isolated from oral mucosa of patients with cancer receiving chemotherapy.
Materials and Methods: In this in vitro study, a total number of 30 patients with oral candidiasis who received chemotherapy were examined. The samples were prepared by using swabs taken from the lesions, and after 48 h, they were transferred and cultured on Sabouraud dextrose agar. The antifungal effect of licorice was compared with nystatin using agar disk diffusion method. These data were entered in SPSS statistical software and were analyzed with Kruskal–Wallis and Mann–Whitney tests. (α = 5%).
Results: Four types of candida were identified among all 30 oral lesions (Candida albicans, Candida glabrata, Candida stellatoidea, and Candida SP). The mean inhibition zone diameter around nystatin showed a significant difference (P < 0.001) between C. albicans (9.486), C. glabrata (8.627), C. stellatoidea (7.00), and C. sp (7.06) but the inhibition zone diameter around licorice was almost zero in all groups.
Conclusion: Licorice extracts did not show any antifungal effects whereas nystatin showed the most antifungal effect against C. albicans.